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Forums / General Yakkity Yak

ecstasy and loud music

33 durable postsStarted 2006-02-16Latest 2006-02-27
#24055Post 1 of 33

[url]http://www.timesonline.co.uk/article/0,,13509-2042662,00.html[/url]

:what

does that affect anyone in here?

#566582Post 2 of 33

Re: ecstasy and loud music

or another version: [url]http://www.scienceagogo.com/news/20060115203449data_trunc_sys.shtml[/url]

#566586Post 3 of 33

Re: ecstasy and loud music

what's ecstasy?

#566588Post 4 of 33

Re: ecstasy and loud music

i especially enjoy this from the second article:

[IMG]http://www.scienceagogo.com/news/img/rats_dancing.jpg[/IMG]

#566590Post 5 of 33

Re: ecstasy and loud music

yep so did i :lol:

#566593Post 6 of 33

Re: ecstasy and loud music

^^^how long do you think they searched for a picture of rats dancing? too funny.

#566597Post 7 of 33

Re: ecstasy and loud music

and they're not dancing on cheese, that's for sure. as a rat, you'd have to be pretty much off your face to don a dresscoat or a dress.

#566598Post 8 of 33

Re: ecstasy and loud music

can anyone explain how tests on mice/rats will give the expected effects on humans??? are these little creatures that close to human beings that scientists can compare the two. someone w/ a chemistry or biology background or knowledge, please enlighten me.

#566599Post 9 of 33

Re: ecstasy and loud music

we should do a study.... how tossed does a rat have to get before it puts on clothing.

#566602Post 10 of 33

Re: ecstasy and loud music

it also looks like he learnt riverdance.

#566603Post 11 of 33

Re: ecstasy and loud music

rats, humans, dinosaurs and the duckbill platipus are all from the same family tree.... i saw that at the local creationist museum..

#566604Post 12 of 33

Re: ecstasy and loud music

and it's not just any rat, it's a "disco rat"....

#566816Post 13 of 33

Re: ecstasy and loud music

Ecstasy and loud music Short cut to brain damage What a revelation

#566817Post 14 of 33

Re: ecstasy and loud music

What a bunch of crap. I really think they don't know what e does to you. So now there fishing for anything to tell people.

#566863Post 15 of 33

Re: ecstasy and loud music

Lucky rats :)

#566904Post 16 of 33

Re: ecstasy and loud music

If only we could somehow get the Pills to multiply like Rats do in order to do a lot of trials to get to the bottom of this quandry.... I'm willing to volunteer every other weekend so long as I can have the following tuesday off from work

#566908Post 17 of 33

Re: ecstasy and loud music

pills are meant to be stuck in your butt.

music goes into the ears.

i do not get this stupid Time article. fucking liberal commie fucks.

#566967Post 18 of 33

Re: ecstasy and loud music

i wonder what they played

#566972Post 19 of 33

Re: ecstasy and loud music

people die every weekend from alcohol.. but the minute someone dies from ecstacy its all over the news. but alcohol is legal.

#566974Post 20 of 33

Re: ecstasy and loud music

[quote=runningman]people die every weekend from alcohol.. but the minute someone dies from ecstacy its all over the news. but alcohol is legal.[/quote]

i dont want disco biscuits sold around the courner, but i do want booze on the other hand is ok

#567222Post 21 of 33

Re: ecstasy and loud music

nah, it's because x deteriorates your brain like no other. It leads to schizophrenia (brain scans revealing meth users compared with those of a schizo show extreme similarities) and other detiorations in the brain. In turn, you get reduced motor abilities and future diseases such as Parkinson's at an early age.

#567269Post 22 of 33

Re: ecstasy and loud music

hence the term, e-tard

#567284Post 23 of 33

Re: ecstasy and loud music

goddamn tweaker rats

#567285Post 24 of 33

Re: ecstasy and loud music

[quote=Lrn]i wonder what they played[/quote]

I thought the same thing. Was it trance,prog, breaks, etc.? Or do the rats like Sasha and Digweed or Tiesto?

#567286Post 25 of 33

Re: ecstasy and loud music

[quote=Localizer]nah, it's because x deteriorates your brain like no other. It leads to schizophrenia (brain scans revealing meth users compared with those of a schizo show extreme similarities) and other detiorations in the brain. In turn, you get reduced motor abilities and future diseases such as Parkinson's at an early age.[/quote] that is most definitely not true. the study to which you are refering to was a study on what was thought to be mdma, but was mislabeled in the lab and later was discovered to actually be methamphetamine. there has never been a study, ever, that has proved that mdma has any long-term effects on the brain.

#574522Post 26 of 33

Re: ecstasy and loud music

[quote=influx]that is most definitely not true. the study to which you are refering to was a study on what was thought to be mdma, but was mislabeled in the lab and later was discovered to actually be methamphetamine. there has never been a study, ever, that has proved that mdma has any long-term effects on the brain.[/quote]

I wasn't referring to the study where the mixed up the 10g shipments.

LMFAO, don't be so naive...There have been numerous studies showing detrimental effects of MDMA on the brain. Go to your local university and look up peer-reviewed journals. In fact you can look up the journals online via google. It does in fact deteriorate your brain and it does show long term damage as well as damage to your short-term memory.

#574530Post 27 of 33

Re: ecstasy and loud music

^^^ In regards to memory loss, there have been other studies which prove otherwise. As a matter of fact, in the study I'm referring to, the top 3 performers were heavy ecstasy users. I can no longer find the link to that study but here's another one which had similar results:

[quote][INDENT][INDENT] [CENTER][B]Researchers Looking for Memory Problems in "Ecstasy" Users Come Up Dry (6/01/03)[/B][/CENTER] [LEFT] In research published this spring in the journal "Cognitive Brain Research" the German government-backed team of Gousoulis-Mayfrank et. al., tested the memory/cognitive performance of heavy and moderate "ecstasy" users vs. non-drug users. The results: Both groups of "ecstasy" users were as mentally sharp as the non-users. In the words of the researchers, "To our surprise, in our study, performance [in the test] revealed no statistically significant group differences[...]" The authors did however note that their tests did not rule out the possibility of impairment in other areas.

[/LEFT] [LEFT] Of interest, brain scans taken while the volunteers underwent memory testing suggested small differences in how the "ecstasy" users were using their brains compared to the non-users, leading the authors to speculate that they may be using "different cognitive strategies." These differences did not correspond to the amount of "ecstasy" individuals had used and may reflect underlying demographic differences between people who seek out psychoactive drugs and those that do not. Journal ref: Cognitive Brain Research vol 16 (2003) pgs. 479-489.[/LEFT] [/INDENT][/INDENT][/quote]

And in regards to the "detrimental effects" and "long term damage" you were referring to, again more FUD being spread by our govt. in order to "protect the children".

The most comprehensive studies are being done by the Germans, who are finding that abstaining from the drug for a period of 3 months reverses the damage, almost to the original baseline (typically 97-98% though).

I would be more concerned the the heart damage, which has real potential with heavy users. It has much the same effect that Fen-Phen does on heart valves, but quite as potently as Fen-Phen. In addition you won't be taking E like people were with Fen-Phen (on average 3 times a day).

If you want good information, backed by studies I suggest you check out [url]www.thedea.org[/url]. Admittedly(sp?), the guy has a bias for the drug, but at the same time he puts out all the information good and bad.

With that said, I would be interested in seeing the studies you are referring to, got any links?

#574551Post 28 of 33

Re: ecstasy and loud music

[quote=Hos][URL="http://www.timesonline.co.uk/article/0,,13509-2042662,00.html"]http://www.timesonline.co.uk/article/0,,13509-2042662,00.html[/URL]

:what

does that affect anyone in here?[/quote]

not in long time

#574555Post 29 of 33

Re: ecstasy and loud music

mdma makes dumb, though it is a nice pleasure from time to time

the problem with drugs is that people who are on will dance to anything.. quality doesn´t really matter. as long as its banging bla.

#574556Post 30 of 33

Re: ecstasy and loud music

im not into that anymore but yes. It used to affect me for days

#574976Post 31 of 33

Re: ecstasy and loud music

[quote=neoee]^^^ In regards to memory loss, there have been other studies which prove otherwise. As a matter of fact, in the study I'm referring to, the top 3 performers were heavy ecstasy users. I can no longer find the link to that study but here's another one which had similar results:

And in regards to the "detrimental effects" and "long term damage" you were referring to, again more FUD being spread by our govt. in order to "protect the children".

The most comprehensive studies are being done by the Germans, who are finding that abstaining from the drug for a period of 3 months reverses the damage, almost to the original baseline (typically 97-98% though).

I would be more concerned the the heart damage, which has real potential with heavy users. It has much the same effect that Fen-Phen does on heart valves, but quite as potently as Fen-Phen. In addition you won't be taking E like people were with Fen-Phen (on average 3 times a day).

If you want good information, backed by studies I suggest you check out [URL="http://www.thedea.org"]www.thedea.org[/URL]. Admittedly(sp?), the guy has a bias for the drug, but at the same time he puts out all the information good and bad.

With that said, I would be interested in seeing the studies you are referring to, got any links?[/quote]

I wish I could receive 98% return to my baseline but with my genetic makeup I don't think that would ever happen ;).

I haven't said anything regarding memory loss but I guess it's safe to correlate brain deterioration with some sort of memory loss. The problem with most studies, especially the one you listed, is that it's focused on serotonic areas (applicable to issues associated with the released of serotonin) and not on dopamergenic neurotoxicity.

Taken from one study: not sure if u can access it but here's the link: [SIZE=4]http://proquest.umi.com/pqdweb?did=205589631&sid=2&Fmt=4&clientId=17916&RQT=309&VName=PQD

[/SIZE]"These findings suggest that humans who use repeated doses of MDMA over several hours are at high risk for incurring severe brain dopaminergic neural injury (along with significant serotonergic neurotoxicity). This injury, together with the decline in dopaminergic function known to occur with age (15), may put these individuals at increased risk for developing Parkinsonism and other neuropsychiatric diseases involving brain dopamine/serotonin deficiency, either as young adults or later in life."

[SIZE=4]Subjects:addSubject("Ecstasy")addSubject("Drug use")addSubject("Memory")addSubject("Cognition & reasoning")addSubject("Studies")generateSubjectTerms() [URL="javascript:searchSideWays('SUB', "Ecstasy")"]Ecstasy[/URL], [URL="javascript:searchSideWays('SUB', "Drug use")"]Drug use[/URL], [URL="javascript:searchSideWays('SUB', "Memory")"]Memory[/URL], [URL="javascript:searchSideWays('SUB', "Cognition & reasoning")"]Cognition & reasoning[/URL], [URL="javascript:searchSideWays('SUB', "Studies")"]Studies[/URL]Author(s):[URL="javascript:void(0);"]John E Fisk[/URL], [URL="javascript:void(0);"]Catharine Montgomery[/URL], [URL="javascript:void(0);"]Philip Murphy[/URL], [URL="javascript:void(0);"]Michelle Wareing[/URL]Document types:FeaturePublication title:[URL="http://proquest.umi.com/pqdweb?RQT=318&pmid=15882&TS=1141005256&clientId=17916&VType=PQD&VName=PQD&VInst=PROD"]British Journal of Psychology[/URL]. London: [URL="http://proquest.umi.com/pqdweb?RQT=572&VType=PQD&VName=PQD&VInst=PROD&pmid=15882&pcid=14271971&SrchMode=3"]Nov 2004[/URL]. Vol. 95 Part 4. pg. 457, 10 pgsPart4Source type:PeriodicalISSN/ISBN:00071269ProQuest document ID:761494371Text Word Count4588Document URL:[url]http://proquest.umi.com/pqdweb?did=761494371&sid=8&Fmt=4&clientId=17916&RQT=309&VName=PQD[/url][/SIZE][IMG]http://proquest.umi.com/images/common/spacer.gif[/IMG] [B]Abstract[/B] (Document Summary)Random letter generation and computation span are tasks known to load on executive, prefrontal resources. Previous research suggests that Ecstasy users are impaired on random letter generation. The current study, employing a larger sample (44 current Ecstasy users, and 59 non-Ecstasy users), together with more effective statistical controls for other drug use, failed to replicate previous findings. Ecstasy users were unimpaired on all measures of random generation performance. A significant difference was obtained on the computation span measure, with Ecstasy users scoring significantly lower than non-Ecstasy users. This difference remained statistically significant following control for various indicators of the use of other drugs including cannabis. The results are discussed in terms of the potential effects that Ecstasy might have on different component executive processes. [PUBLICATION ABSTRACT]

Another link since this one is in .pdf. I'll post more when i'm done watching sin city. [url]http://proquest.umi.com/pqdweb?index=6&did=754591671&SrchMode=1&sid=8&Fmt=6&VInst=PROD&VType=PQD&RQT=309&VName=PQD&TS=1141005227&clientId=17916[/url]

Another huge problem that is posed is that the external validity is going down with the german experiments because they seemed very controlled. Most users of mdma don't take pure mdma, but mdma coupled with other drugs, and this is where we have a huge problem because the coupling of those drugs may actually be the issue for deterioration. The combination of MDMA working with other drugs.

#575013Post 32 of 33

Re: ecstasy and loud music

What about the monkey smoking the cigar ?

#575031Post 33 of 33

Re: ecstasy and loud music

[quote=Localizer]I wish I could receive 98% return to my baseline but with my genetic makeup I don't think that would ever happen ;).[/quote] Sorry to hear that its taken such a toll on you. I hope things DO return back to baseline for you.

[quote=Localizer] I haven't said anything regarding memory loss but I guess it's safe to correlate brain deterioration with some sort of memory loss. [/quote] Actually you did mention memory loss in your earlier statement:

[quote=Localizer]...well as damage to your short-term memory.[/quote]

[quote=Localizer] Taken from one study: not sure if u can access it but here's the link: [SIZE=4]http://proquest.umi.com/pqdweb?did=205589631&sid=2&Fmt=4&clientId=17916&RQT=309&VName=PQD

[/SIZE]"These findings suggest that humans who use repeated doses of MDMA over several hours are at high risk for incurring severe brain dopaminergic neural injury (along with significant serotonergic neurotoxicity). This injury, together with the decline in dopaminergic function known to occur with age (15), may put these individuals at increased risk for developing Parkinsonism and other neuropsychiatric diseases involving brain dopamine/serotonin deficiency, either as young adults or later in life."[/quote] Unfortunately I do not have access to the site so I couldn't see the data. However, this looks like a repeat of the claims that Ricartue et al. were making. Just a reminder, the reason he was forced to retract his study was due the the pressure from other scientists that could not duplicate the results and then his final retraction claiming "the bottles were mislabeled." He was the one that originally made the claim of Parkinsonism, and that was the study in particular that was retracted. More info on that, if your interested: [URL="http://www.maps.org/mdma/retraction/maps_response_100203.html"]http://www.maps.org/mdma/retraction/maps_response_100203.html[/URL]

[quote=Localizer][SIZE=4]Subjects:addSubject("Ecstasy")addSubject("Drug use")addSubject("Memory")addSubject("Cognition & reasoning")addSubject("Studies")generateSubjectTerms() [URL="http://javascript%3Cb%3E%3C/b%3E:searchSideWays%28%27SUB%27,%20"Ecstasy"%29"]Ecstasy[/URL], [URL="http://javascript%3Cb%3E%3C/b%3E:searchSideWays%28%27SUB%27,%20"Drug%20use"%29"]Drug use[/URL], [URL="http://javascript%3Cb%3E%3C/b%3E:searchSideWays%28%27SUB%27,%20"Memory"%29"]Memory[/URL], [URL="http://javascript%3Cb%3E%3C/b%3E:searchSideWays%28%27SUB%27,%20"Cognition%20&%20reasoning"%29"]Cognition & reasoning[/URL], [URL="http://javascript%3Cb%3E%3C/b%3E:searchSideWays%28%27SUB%27,%20"Studies"%29"]Studies[/URL]Author(s):[URL="http://javascript%3Cb%3E%3C/b%3E:void%280%29;"]John E Fisk[/URL], [URL="http://javascript%3Cb%3E%3C/b%3E:void%280%29;"]Catharine Montgomery[/URL], [URL="http://javascript%3Cb%3E%3C/b%3E:void%280%29;"]Philip Murphy[/URL], [URL="http://javascript%3Cb%3E%3C/b%3E:void%280%29;"]Michelle Wareing[/URL]Document types:FeaturePublication title:[URL="http://proquest.umi.com/pqdweb?RQT=318&pmid=15882&TS=1141005256&clientId=17916&VType=PQD&VName=PQD&VInst=PROD"]British Journal of Psychology[/URL]. London: [URL="http://proquest.umi.com/pqdweb?RQT=572&VType=PQD&VName=PQD&VInst=PROD&pmid=15882&pcid=14271971&SrchMode=3"]Nov 2004[/URL]. Vol. 95 Part 4. pg. 457, 10 pgsPart4Source type:PeriodicalISSN/ISBN:00071269ProQuest document ID:761494371Text Word Count4588Document URL:[URL="http://proquest.umi.com/pqdweb?did=761494371&sid=8&Fmt=4&clientId=17916&RQT=309&VName=PQD"]http://proquest.umi.com/pqdweb?did=761494371&sid=8&Fmt=4&clientId=17916&RQT=309&VName=PQD[/URL][/SIZE][IMG]http://proquest.umi.com/images/common/spacer.gif[/IMG] [B]Abstract[/B] (Document Summary)Random letter generation and computation span are tasks known to load on executive, prefrontal resources. Previous research suggests that Ecstasy users are impaired on random letter generation. The current study, employing a larger sample (44 current Ecstasy users, and 59 non-Ecstasy users), together with more effective statistical controls for other drug use,[B] failed to replicate previous findings. Ecstasy users were unimpaired on all measures of random generation performance.[/B] A significant difference was obtained on the computation span measure, with Ecstasy users scoring significantly lower than non-Ecstasy users. This difference remained statistically significant following control for various indicators of the use of other drugs including cannabis. The results are discussed in terms of the potential effects that Ecstasy might have on different component executive processes. [PUBLICATION ABSTRACT]

Another link since this one is in .pdf. I'll post more when i'm done watching sin city. [URL="http://proquest.umi.com/pqdweb?index=6&did=754591671&SrchMode=1&sid=8&Fmt=6&VInst=PROD&VType=PQD&RQT=309&VName=PQD&TS=1141005227&clientId=17916"]http://proquest.umi.com/pqdweb?index=6&did=754591671&SrchMode=1&sid=8&Fmt=6&VInst=PROD&VType=PQD&RQT=309&VName=PQD&TS=1141005227&clientId=17916[/URL]

[/quote] Again I don't have access to the site, but based on the excerpt you posted, and if I'm reading it properly it goes against what you mentioned (in bold)

[quote=Localizer]Another huge problem that is posed is that the external validity is going down with the german experiments because they seemed very controlled. Most users of mdma don't take pure mdma, but mdma coupled with other drugs, and this is where we have a huge problem because the coupling of those drugs may actually be the issue for deterioration. The combination of MDMA working with other drugs.[/quote] Agreed. This has been a problem for all the studies being done. Since the earlier studies were not government approved they basically had to take people that took the drug on their own, without any controls in place. With the two FDA approved studies that are currently taking place I hope they can come to some better conclusions though I'm doubtful, since they are measuring primarily the theraputic effects of the drug.

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